![]() ![]() Transplantation of hOPCs increased the fluorescence intensity of myelin basic protein and the thickness of myelin sheaths as observed in immunostaining and transmission electron microscopy, while it reduced white matter atrophy at the level of gross morphology. Notably, 82.77 ± 3.27% of transplanted cells differentiated into mature oligodendrocytes, which produced myelin around the axons. They were widely distributed in the injured white matter, and migrated along the corpus callosum to the contralateral hemisphere. Results: Transplanted hOPCs survived for 13 weeks in PWMI brains. Histological analyses, as well as immunohistochemical and transmission electron microscopy, were performed after transcardial perfusion. Neurobehavior was assessed 12 weeks post-transplant using the CatWalk test and Morris water maze test. Methods: Hypoxia-ischemia was induced in rats at postnatal day 3, and hOPCs (6 × 10 5 cells/5 μL) were intracerebroventricularly transplanted at postnatal day 7. This study aimed to investigate the fate and effectiveness of transplanted human oligodendrocyte progenitor cells (hOPCs) in a rat model of PWMI. ![]() ![]() Background: Preterm white matter injury (PWMI) is a common brain injury and a leading cause of life-long neurological deficits in premature infants however, no effective treatment is available yet. ![]()
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